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Some studies show 70% to 88.9% of patients with HS being smokers

This protein acts as both an antioxidant and a structural component in developing sperm

WARNINGS: Patients with early Leber's disease (hereditary optic nerve atrophy) who were treated with cyanocobalamin suffered severe and swift optic atrophy

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Gastrointestinal surgery significantly increases risk, particularly procedures involving the stomach (gastrectomy) or terminal ileum resection, as these remove or bypass critical absorption sites